Relationship of fat mass and serum estradiol with lower extremity bone in persons with chronic spinal cord injury.
نویسندگان
چکیده
In the spinal cord injury (SCI) population, a relationship between adiposity and leg bone has not been reported, nor one between serum estradiol and leg bone mass. A cross-sectional, comparative study of 10 male pairs of monozygotic twins discordant for SCI was performed. Relationships were determined among bone mineral density (BMD), bone mineral content (BMC), lean mass, fat mass, and serum sex steroids. In the twins with SCI, significant relationships were evident between leg BMD or BMC with total body percent fat (r2= 0.49, P < 0.05; r2= 0.45, P = 0.05), leg fat mass (r2 = 0.76, P < 0.0005; r2= 0.69, P = 0.005), and serum estradiol (r2= 0.40, P = 0.05; r2= 0.37, P = 0.05). By stepwise regression analysis, in the twins with SCI, leg fat mass was found to be the single most significant predictor of leg BMD or BMC (F = 12.01, r2= 0.76, P = 0.008; F = 50.87, r2= 0.86, P < 0.0001). In the able-bodied twins, leg lean mass correlated with leg BMD and BMC (r2= 0.58, P = 0.01; r2= 0.87, P = 0.0001). By use of within-pair differences, significant correlations were found for leg lean mass loss with leg BMD loss (r2= 0.56, P = 0.01) or leg BMC loss (r2= 0.64, P = 0.0005). In conclusion, in twins with SCI, significant correlations were observed between fat mass and leg BMD or BMC as well as between serum estradiol values and leg BMD. The magnitude of the leg muscle mass loss was correlated with the magnitude of bone loss.
منابع مشابه
بررسی تاثیر تمرین با حمایت وزن (BWSTT) بر نیمرخ حرکتی عملکردی افراد ضایعه نخاعی پاراپلژی
Purpose: This study aimed to examine the effect of Body-Weight-Supported Treadmill Training (BWSTT) exercises on functional ambulation profile in patients with paraplegic spinal cord injury. Methods: This was a quasi experimental study with pre test and post test. The statistical population consisted of paraplegia spinal cord injured persons in Shahrekord City. Seventeen voluntary patient...
متن کاملبررسی وضعیت استخوانی در افراد دارای آسیب نخاعی
Background: Bone loss in spinal cord injured patients is common problem. Based on high prevalence of osteoporosis in these patients, this study was designed for the first time to evaluate bone mineral density and related markers in spinal cord injured patients. Methods: Inpatients with chronic spinal cord injury who was referring to the clinic of spinal cord injury research center were recru...
متن کاملEffect of Intravenous Injection of Erythropoietinon Hospitalization Period in Patients with Acute Spinal Cord Trauma
Background & Aim: Spinal cord injury (SCI) has a very long history, and its cases form a large proportion of patients admitted to trauma centers in Iran. Studies show that repair after spinal cord injury can be done. In fact, many pharmaceutical agents, such as erythropoietin (EPO), are applied to reduce secondary injury following the initial disorder and to maintain the nerve tissue. Methods &...
متن کاملA Case of Gunshot Injury to the Spinal Cord in a Dog: Clinical, Surgical, and X-ray Features.
Case description- A five-year-old female dog, weighing 35 kg, was presented as an emergency case after it suffered a gunshot injury.Clinical findings - Physical examination of the dog revealed paraplegia, the symptoms were normal. There was no bone fracture and dislocation in the lower extremity examination. A bullet (diameter, 4 mm) between the third and fourth lumbar was observed on rad...
متن کاملبررسی دریافت غذایی مبتلایان به ضایعه نخاعی بر اساس جنس، متغیرهای وابسته به ضایعه و چاقی در مرکز تحقیقات ترمیم ضایعات مغزی و نخاعی تهران
Background & Objectives: Despite an increased risk of obesity and CHD in people with spinal cord injury (SCI), there is little known about the dietary intake in this group, therefore the aim of this study was to examine nutrient intake and body mass index (BMI) in the spinal cord injury (SCI) population according to level of injury and related variables. Methods: In this cross-sectional stu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- American journal of physiology. Endocrinology and metabolism
دوره 290 6 شماره
صفحات -
تاریخ انتشار 2006